Secretary of State John Kerry’s recent visit to Islamabad for attending the second edition of the revitalized Pak-US Strategic Dialogue provides a useful opportunity to evaluate the potential and the future prospects of Pakistan-US friendship against the background of the evolving regional and global scenarios. An accurate understanding of the convergence and the divergence of the interests of the two countries in a dynamic setting is an essential prerequisite for judging the long-term worth of this vital relationship. An analysis on these lines reveals that whereas Pakistan’s friendship with the US must remain an enduring factor in Pakistan’s foreign policy for the foreseeable future, it would be a mistake to attach exaggerated expectations to it because of the likely evolution of the regional and global scenarios.